Growth patterns during the first two years of life in children with a history of perinatal asphyxia treated with therapeutic hypothermia: longitudinal retrospective study
Growth patterns of children with perinatal asphyxia
DOI:
https://doi.org/10.14306/renhyd.28.1.1942Keywords:
perinatal asphyxia, Growth, nutritional status, therapeutic hypothermia, Infant Nutrition DisordersAbstract
Introduction: Perinatal asphyxia (PA) is a high-risk obstetric complication for the development of organic and functional alterations that can lead to states of malnutrition, with all the adverse effects that these entail on health and human development. The objective of the present study was to describe the physical growth patterns presented during the first two years of life in a sample of children with a history of PA.
Methods: Descriptive, retrospective, and longitudinal study, in 52 cases of children with a history of AP who attended a comprehensive follow-up and care program during the first 24 months of age. Growth trends were determined based on what was established by the WHO (2006), classifying children according to the changes observed on the score-z of anthropometric indicators. All children chosen for the study were treated with therapeutic hypothermia.
Results: 38.5% of the cases presented malnutrition trajectories without recovery, with chronic malnutrition being the predominant growth alteration. The Delayed intrauterine growth (PR = 1.61, IC95%: 1.028 – 2.529), weight-length ratio for gestational age less than the 10th percentile (PR = 1.37, 95% CI: 1.021 – 1.849), the work (PR = 1.59, IC95%: 1.119 – 2.265) and a lower educational level of the mother (PR = 1.40, IC 95%: 1.041 – 1.899) were significantly associated with child malnutrition.
Conclusions: Malnutrition trajectories represented a frequent problem in the study group, so it is considered important to continue this line of research to determine the prevalence of growth alterations in children with this and other pathological conditions.
References
(1) Herrera M, Neira T, Rojas E, Espina P, Esmar D, Pérez R, et al. Perinatal asphyxia: CNS development and deficits with delayed onset. Front Neurosci. 2014;8(47), doi: 10.3389/fnins.2014.00047.
(2) Herrera I, Kobeik T, Kölliker-Frers R, Otero-Losada M, Capani F. Synaptoprotection in Perinatal Asphyxia: An Experimental Approach. Front Synaptic Neurosci. 2020;12(35), doi: 10.3389/fnsyn.2020.00035.
(3) Dekkers L, Janssen A, Steiner K, Maas-van N, Akkermans R, de Swart B, et al. Individual longitudinal neurodevelopmental trajectories of children treated with hypothermia for perinatal asphyxia from 3 months to 5 years of age. Res Dev Disabil. 2020;102, doi: 10.1016/j.ridd.2020.103659.
(4) Abate B, Bimerew M, Gebremichael B, Mengesha A, Kassaw M, Gebremeskel Teshome, et al. Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxicischemic encephalopathy: A systematic review and meta-analysis of randomized control trials. PLoS ONE. 2021;16(2):e0247229, doi: 10.1371/journal.pone.0247229.
(5) Vélez A, Orozco G, Flores-Compadre JL, Cruz F. Hipoxia perinatal y su impacto en el neurodesarrollo. Rev Chil Neuropsicol. 2013;8(1):26-31.
(6) Krüger E, Kritzinger A, Pottas L. Breastfeeding and swallowing in a neonate with mild hypoxic ischaemic encephalopathy. S Afr J Common Disord. 2017;64(1):1-7, doi: 10.4102/sajcd.v64i1.209.
(7) Alzamora I, Oscorima J, Advíncula C, Castro G, Ramos E. Manejo nutricional en un paciente pediátrico con Encefalopatía hipóxica isquémica, síndrome obstructivo bronquial y retardo en el crecimiento. ReNut. 2013;4(13):654-66.
(8) Lau C. Breastfeeding Challenges and the Preterm Mother-Infant Dyad: A Conceptual Model. Breastfeed Med. 2018;13(1):8-17, doi: 10.1089/bfm.2016.0206.
(9) Aslam S, Strickland T, Molloy E. Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management. Front Pediatr. 2019;7, doi: 10.3389/fped.2019.00142.
(10) Quirke F, Ariff S, Bernard C, Bloomfield F, Daly M, Devane D, et al. Core outcomes in neonatal encephalopathy: a qualitative study with parents. BMJ Paediatrics Open. 2022;6:e001550, doi: 10.1136/ bmjpo-2022-001550.
(11) Torres A. Crecimiento y desarrollo. Rev Mex Med Fis Rehab. 2002;14(24):54-7.
(12) Márquez H, García V, Caltendo M de L, García E, Márquez H, Villa A. Clasificación y evaluación de la desnutrición en el paciente pediátrico. Residente. 2012;7(2):59-69.
(13) Gómez R, Arruda M, Luarte C, Urra C, Almonacid A, Cossio B. Enfoque teórico del crecimiento físico de niños y adolescentes. Rev Esp Nutr Hum Diet. 2016;20(3):244-53, doi: 10.14306/renhyd.20.3.198.
(14) Ramos-Galván R. Desnutrición, un componente del síndrome de privación social. G Méd Méx. 1966;96(9):929-42.
(15) González N, López G, Prado L. Importancia de la nutrición: primeros 1,000 días de vida. Act Ped Hond. 2016;7(1):597-604.
(16) Bolioli P, Alonso S, Parodi M, Méndez M, Rebufo N, Lucas J. Falla de crecimiento en niños menores de 24 meses. Arch Pediatr Urug. 2003;74(4):245-54.
(17) Caiza Sánchez M a E, Díaz Rosselló JL, Simini F. Índice ponderal para calificar a una población de recién nacidos a término. Anales de Pediatría. 2003;59(1):48-53, doi: 10.1016/S1695-4033(03)78147-8.
(18) Universidad de Oxford. The International Fetal and Newborn Growth Consortium for the 21st Century. 2021.
(19) Flores S, Martínez H. Peso al nacer de los niños y niñas derechohabientes del Instituto Méxicano del Seguro Social. Bol Med Hosp Infant Mex. 2012;69(1):30-9.
(20) Villar J, Puglia F, Fenton T, Cheikh L, Staines E, Giuliani F, et al. Body composition at birth and its relationship with neonatal anthropometric ratios: the newborn body composition study of the INTERGROWTH-21st project. Pediatr Res. 2017;82:305-16, doi: https://doi.org/10.1038/pr.2017.52.
(21) Organización Mundial de la Salud. Growth Standards. Geneve; 2006.
(22) Bolzán A, Gatella ME, Cotti M. Aplicación de dos métodos diagnósticos para evaluar el estado nutricional de una población infantil: Enfoque epidemiológico y enfoque de punto de corte. Rev Chil Pediatr. 2005;76(5):485-93, doi: https://doi.org/dvkrsv.
(23) Abeyá E, Calvo E, Durán P, Mazza C. Evaluación del estado nutricional de niñas, niños y embarazadas mediante antropometría. 2009.
(24) Cesaní MF, Oyhenart E. La desnutrición crónica y su efecto generacional sobre el crecimiento. Aporte de los estudios de antropología biológica experimental. En: Paschetta C, González-José R, Lanata JL, editores. De como cruzar fronteras en la ciencia. Homenaje a Héctor M. Pucciarelli. 1ra edición compendida. Argentina: UNRN-CONICET; 2017. p. 43-57.
(25) Tejada M, Gónzalez A, Márquez Y, Bastardo L. Escolaridad materna y desnutrición del hijo o hija. Centro Clínico Nutricional Menca de Leoni. Caracas. An Venez Nutr. 2005;18(2):162-8.
(26) Torres MF, Bergel ML, Aníbal F, Navazco B, Luna ME, Cesani MF. Influencia del nivel educativo materno sobre el estado nutricional infantil y adolescente (La Palta, Buenos Áires, Argentina). Runa. 2022;43(2):137-55, doi: https://doi.org/kw2g.
(27) Pally E, Mejía H. Factores de riesgo para desnutrición aguda grave en niños menores de cinco años. Rev Soc Boliv Pediatr. 2012;51(2):90-6, doi: lil-738293.
(28) Murcia C, Preciado H, Blanco D, Rojas L, Noguera L, Villar J. Restricción del crecimiento intrauterino: Complicaciones inmediatas. Repert Med Cir. 2012;21(4):250-5, doi: 10.31260/RepertMedCir.v21.n4.2012.825.
(29) Pimiento L, Beltrán M. Restricción del crecimiento intrauterino: Una aproximación al diagnóstico, seguimiento y manejo. Rev Chil Obstet Ginecol. 2015;80(6):493-502, doi: 10.4067/S0717-75262015000600010.
(30) Victoria C, Bahl R, Barros A, França G, Horton S, Krasevec J. Breastfeeding in the 21st century epidemiology, mechanisms, and lifelong effect. The Lancet. 2016;387(10017):475-90, doi: https://doi.org/cv86.
(31) Woodward L, Liberty K. Lactancia materna y desarrollo psicosocial del niño. Enciclopedia sobre el Desarrollo de la Primera Infancia. 2017.
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Miguel Angel Hernández Real, María Magdalena Sánchez Jesús , Patricia Muñoz-Ledo Rábago , Mario António Mandujano Valdés , María Rodríguez Flores
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
This journal 