Existing evidence on the influence of prebiotic intake on the risk of colorectal cancer
DOI:
https://doi.org/10.14306/renhyd.17.1.1Keywords:
colorectal cancer, prebiotics, inulinAbstract
Colorectal cancer is one of the most common cancers worldwide. Among the risk of developing colorectal cancer and the intestinal microbiota there is a complex relationship that can be modified by diet. The effect of prebiotics on the composition and colonic microbiota activity can produce beneficial changes in the altered flora of pacients with colon cancer. Of all the prebiotic inulin HP and sinergil (30% oligofructose and 70% inulin) are supposed to be the ones that keep a closer relationship with the tumor. This phenomenon could be explained by the long chain fructans. The animal studies observed that administration of prebiotics reduces the number and multiplicity of aberrant crypt foci, reduce the number and lifetime of the tumors, inhibits their growth and potentiates the effect of different chemotherapeutic drugs. The results obtained in rodents that are intended to simulate genetic predisposition are not homogeneous. Some human studies, mostly healthy, observed changes in the composition of the microbiota, in the bile acid profile and the short chain fatty acids, but the results differ among studies and no conclusive results are obtained.
References
McGarr SE, Ridlon JM, Hylemon PB. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol 2005;39(2):98-109. PubMed PMID: 15681903.
Tappenden KA, Deutsch AS. The physiological relevance of the intestinal microbiota--contributions to human health. J Am Coll Nutr. 2007;26 Suppl(6):679-683. PubMed PMID: 18187433.
Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiol Rev 2010;90(3):859-904. PubMed PMID: 20664075.
Davis CD, Milner JA. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 2009;20(10):743-52. PubMed PMID: 19716282.
Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, et al. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr 2007;85(2):488-96. PubMed PMID: 17284748.
Rastall RA. Bacteria in the gut: friends and foes and how to alter the balance. J Nutr 2004;134(8 Suppl):2022-2026. PubMed PMID: 15284393.
Hijova E, Chmelarova A. Short chain fatty acids and colonic health. Bratisl Lek Listy 2007;108(8):354-8. PubMed PMID: 18203540.
Wong JM, Souza R, Kendall CW, Emam A, Jenkins DJ. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 2006;40(3):235-43. PubMed PMID: 16633129.
Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ. Review article: the role of butyrate on colonic function. Aliment Pharmacol Ther 2008 Jan;27(2):104-19. PubMed PMID: 17973645.
Eurostat (internet web) . Health statistics - Athlas on mortality in the European Union. 2011. Available from: http://epp.eurostat.ec.europa.eu/portal/page/portal/product_details/publication?p_product_code=KS-30-08-357
Instituto Nacional de Estadística (INE) . Defunciones según la cause de muerte: Año 2008. 2010. Available from: http://www.ine.es/jaxi/menu.do?type=pcaxis&path=/t15/p417&file=inebase&L=0
Pearson JR, Gill CI, Rowland IR. Diet, fecal water, and colon cancer--development of a biomarker. Nutr Rev 2009;67(9):509-26. PubMed PMID: 19703259.
Rafter J, Govers M, Martel P, Pannemans D, Pool-Zobel B, Rechkemmer G, et al. PASSCLAIM--diet-related cancer. Eur J Nutr 2004;43(Suppl 2):47-84. PubMed PMID: 15221354.
Roberfroid M, Gibson GR, Hoyles L, McCartney AL, Rastall R, Rowland I, et al. Prebiotic effects: metabolic and health benefits. Br J Nutr. 2010;104(Suppl 2):1-63. PubMed PMID: 20920376.
Roberfroid M. Prebiotics: the concept revisited. J Nutr 2007;137(Suppl 2):830-837. PubMed PMID: 17311983.
Kelly G. Inulin-type prebiotics--a review: part 1. Altern Med Rev 2008;13(4):315-29. PubMed PMID: 19152479.
Pool-Zobel B, van_Loo J, Rowland I, Roberfroid MB. Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer. Br J Nutr. 2002;87(Suppl 2):273-281. PubMed PMID: 12088529.
Roberfroid MB. Inulin-type fructans: functional food ingredients. J Nutr. 2007;137(Suppl 11):2493-2502. PubMed PMID: 17951492.
Liong MT. Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence. Int J Mol Sci 2008;9(5):854-63. PubMed PMID: 19325789.
Preter, V. de , Vanhoutte T, Huys G, Swings J, Rutgeerts P, Verbeke K. Baseline microbiota activity and initial bifidobacteria counts influence responses to prebiotic dosing in healthy subjects. Aliment Pharmacol Ther 2008 Mar;27(6):504-13. PubMed PMID: 18081736.
Duarte PM, Gonçalves MPF, Teixeira JA, Rodrigues LR. Galacto-oligosaccharides: production, properties, applications, and significance as prebiotics. Compr Rev Food Sci Food Saf 2010;9:438-454.
Kelly G. Inulin-type prebiotics: a review (Part 2). Altern Med Rev 2009;14(1):36-55. PubMed PMID: 19364192.
Pool-Zobel BL. Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br J Nutr. 2005;93(Suppl 1):73-90. PubMed PMID: 15877900.
Verghese M, Rao DR, Chawan CB, Williams LL, Shackelford L. Dietary inulin suppresses azoxymethane-induced aberrant crypt foci and colon tumors at the promotion stage in young Fisher 344 rats. J Nutr 2002;132(9):2809-13. PubMed PMID: 12221250.
Taper HS, Lemort C, Roberfroid MB. Inhibition effect of dietary inulin and oligofructose on the growth of transplantable mouse tumor. Anticancer Res 1998;18(6A):4123-6. PubMed PMID: 9891456.
Taper HS, Roberfroid M. Influence of inulin and oligofructose on breast cancer and tumor growth. J Nutr 1999;129(Suppl 7):1488-1491. PubMed PMID: 10395627.
Taper HS, Roberfroid MB. Inhibitory effect of dietary inulin or oligofructose on the development of cancer metastases. Anticancer Res 2000;20(6B):4291-4. PubMed PMID: 11205260.
Taper HS, Roberfroid MB. Nontoxic potentiation of cancer chemotherapy by dietary oligofructose or inulin. Nutr Cancer 2000;38(1):1-5. PubMed PMID: 11341034.
Taper HS, Roberfroid MB. Inulin/oligofructose and anticancer therapy. Br J Nutr 2002;87(Suppl 2):283-286. PubMed PMID: 12088530.
Pierre F, Perrin P, Champ M, Bornet F, Meflah K, Menanteau J. Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Res 1997 Jan;57(2):225-8. PubMed PMID: 9000559.
Mutanen M, Pajari AM, Oikarinen SI. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Carcinogenesis 2000;21(6):1167-73. PubMed PMID: 10837006.
Pajari AM, Rajakangas J, Päivärinta E, Kosma VM, Rafter J, Mutanen M. Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic beta-catenin in Min mice. Int J Cancer 2003 Sep;106(5):653-60. PubMed PMID: 12866023.
Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 2002;23(11):1953-60. PubMed PMID: 12419846.
Bouhnik Y, Flourié B, Riottot M, Bisetti N, Gailing MF, Guibert A, et al. Effects of fructo-oligosaccharides ingestion on fecal bifidobacteria and selected metabolic indexes of colon carcinogenesis in healthy humans. Nutr Cancer 1996;26(1):21-9. PubMed PMID: 8844718.
Scholtens PA, Alles MS, Willemsen LE, van den Braak C, Bindels JG, Boehm G, et al. Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial. Br J Nutr 2006;95(6):1143-9. PubMed PMID: 16768837.
Bouhnik Y, Achour L, Paineau D, Riottot M, Attar A, Bornet F. Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutr J 2007 Dec;6:42. PubMed PMID: 18053236.
Boutron-Ruault MC, Marteau P, Lavergne-Slove A, Myara A, Gerhardt MF, Franchisseur C, et al. Effects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal denomas. Nutr Cancer 2005;53(2):160-8. PubMed PMID: 16573377.
Alles MS, Hartemink R, Meyboom S, Harryvan JL, Van Laere KM, Nagengast FM, et al. Effect of transgalactooligosaccharides on the composition of the human intestinal microflora and on putative risk markers for colon cancer. Am J Clin Nutr 1999;69(5):980-91. PubMed PMID: 10232640.
Van Dokkum W, Wezendonk B, Srikumar TS, Van den Heuvel EG. Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr 1999;53(1):1-7. PubMed PMID: 10048793.
Worthley DL, Le leu RK, Whitehall VL, Conlon M, Christophersen C, Belobrajdic D, et al. A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 2009;90(3):578-86. PubMed PMID: 19640954.
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