Mecanismos moleculares implicados en los posibles efectos de los compuestos fenólicos en la disminución del riesgo de enfermedades cardiovasculares
DOI:
https://doi.org/10.14306/renhyd.17.3.22Palabras clave:
Enfermedades cardiovasculares, Polifenoles, Antioxidantes, Prevención primariaResumen
El objetivo de la presente revisión es evaluar los mecanismos implicados en la posible asociación entre los polifenoles y la disminución del riesgo de padecer enfermedades cardiovasculares, postulando que su consumo habitual en la dieta occidental podría resultar beneficioso para la protección de los pacientes frente las enfermedades cardiovasculares. Se realizó una extensa búsqueda de publicaciones científicas recientes en las siguientes bases de datos electrónicas especializadas: PubMed central (PMC)-NBCI, Elsevier Journal, Scielo España, Scirus, Science Direct, Web of Science, incluyendo estudios en células, animales y humanos, sobre el efecto de los polifenoles en la prevención y desarrollo de enfermedades cardiovasculares. Los estudios in vitro, en modelos animales y en humanos, muestran la capacidad potencial de los compuestos fenólicos para actuar frente a enfermedades cardiovasculares debido a su acción antioxidante, vasodilatadora y de mejora de los perfiles lipídicos con atenuación de las lipoproteínas de baja densidad. Su consumo habitual en la dieta occidental podría resultar beneficioso para la protección de los pacientes frente las enfermedades cardiovasculares.
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