Coffee consumption as a protective factor against oral and pharyngeal cancer: critical analysis of the literature
DOI:
https://doi.org/10.14306/renhyd.23.3.650Keywords:
Coffee, Caffeine, Mouth Neoplasms, Pharyngeal Neoplasms, Risk.Abstract
The high and unequal prevalence of oral and pharyngeal cancer, together with the high consumption of coffee worldwide, make studies to analyze how the consumption of these drinks containing methylxanthines contributes, in the risk of these neoplasms, although with contradictory results. The objective of the present study was to verify the validity and applicability of the results regarding the effectiveness of high coffee consumption in adults as a protective factor for oral and pharyngeal cancer and answer the following question: ¿can a high consumption of coffee in drink be a protective factor against oral and pharyngeal cancer? The article by Miranda et al (2017) was analyzed: “Coffee is protective against oral and pharyngeal cancer: a systematic review and meta-analysis”. A significant protective association was found between coffee consumption and the risk of oral cancer, and especially pharyngeal (z = 2.34, p = 0.019, OR = 0.72), inferring that the development of oral cancer in individuals who consume large amounts of coffee is 1.45 times lower than in individuals who consume small quantities or do not consume (OR = .69; 95% CI = .57-.84). However, with the methodological limitations of the primary studies included in the systematic review with meta-analysis, we do not consider the current moderate evidence sufficient to recommend the consumption of high quantities of the beverage of coffee to prevent oral or pharyngeal cancer in adults.
References
(1) Siegel R, Miller K, Jemal A. Cancer statistics 2015. CA Cancer J Clin. 2015;65(1):5–29.
(2) Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009;45(4–5):309–16.
(3) Strasser-Weippl K, Chavarri-Guerra Y, Villarreal-Garza C, Bychkovsky B, Debiasi M, Liedke P, et al. Progress and remaining challenges for cancer control in Latin America and the Caribbean. Lancet Oncol. 2015;16(14):1405–38.
(4) Siegel R, Miller K, Jemal A. Cancer statistics, 2017. Cancer J Clin. 2017;67(1):7–30.
(5) Macedo da Silva, Bonfante Gisele Machado CJ, Alencar de Souza PE, Gurgel Andrade EI, de Assis Acurcio F, Cherchiglia Leal M. Specific 5-year oral cancer survival and associated factors in cancer outpatients in the Brazilian Unified National Health System. Cad Saúde Pública. 2014;30(5):983–97.
(6) Hashibe M, Brennan P, Chuang sc Boscia S, Castellsague X, Chen C. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the international head and cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 2009;18:541–50.
(7) de Menezes R, Bergmann A, Sales de Aguilar S, Santos Thuler L. Alcohol consumption and the risk of cancer in Brazil: A study involving 203,506 cancer patients. Alcohol. 2015;49(7):747–51.
(8) Garavello W, Lucenteforte E, Bosetti C, La Vecchia C. The role of foods and nutrients on oral and pharyngeal cancer risk. Minerva Stomatol. 2009;58(1–2):25–34.
(9) Naganuma T, Kuriyama S, Kakizaki M, Sone T, Nakaya N, Ohmori-Matsuda K, et al. Coffee Consumption and the Risk of Oral, Pharyngeal, and Esophageal Cancers in Japan: The Miyagi Cohort Study. Am J Epidemiol. 2008;168(12):1425–32.
(10) Tavani A, Bertuzzi M, Talamini R, Gallus S, Parpinel M, Franceschi S, et al. Coffee and tea intake and risk of oral, pharyngeal and esophageal cancer. Oral Oncol. 2003;39(7):695–700.
(11) Ren JS, Freedman ND, Kamangar F, Dawsey SM, Hollenbeck AR, Schatzkin A, et al. Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort study. Eur J Cancer. 2010;46(10):1873–81.
(12) Franco E, Kowalski L, Oliveira B, Curado M, Pereira R, Silva M, et al. Risk factors for oral cancer in Brazil: a case-control study. Int J Cancer. 1989;43:992–1000.
(13) Bundgaard T, Wildt J, Frydenberg M, Elbrønd O, Nielsen J. Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control. 1995;6:57–67.
(14) Rodriguez T, Altieri A, Chatenoud L, Gallus S, Bosetti C, Negri E, et al. Risk factors for oral and pharyngeal cancer in young adults. Oral Oncol. 2004;40(2):207–13.
(15) Zhang Y, Wang X, Cui D. Association between coffee consump¬tion and the risk of oral cancer: a meta-analysis of observational studies. Int J Clin Exp Med. 2015;8:11657–65.
(16) Li Y, Peng J, Li L. Coffee consumption associated with re¬duced risk of oral cancer: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:381–9.
(17) Loomis D, Guyton KZ, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, et al. Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncol. 2016;17(7):877–8.
(18) Daglia M, Papetti A, Gregotti C, Bertè F, Gazzani G. In Vitro Antioxidant and ex Vivo Protective Activities of Green and Roasted Coffee. J Agric Food Chem. 2000 May 1;48(5):1449–54.
(19) Pischetsrieder M, Rinaldi F, Gross U, Severin T. Assessment of the Antioxidative and Prooxidative Activities of Two Aminoreductones Formed during the Maillard Reaction: Effects on the Oxidation of β-Carotene, Nα-Acetylhistidine, and cis-Alkenes. J Agric Food Chem. 1998 Aug 17;46(8):2945–50.
(20) Hashimoto T, He Z, Ma W-Y, Schmid PC, Bode AM, Yang CS, et al. Caffeine Inhibits Cell Proliferation by G<sub>0</sub>/G<sub>1</sub> Phase Arrest in JB6 Cells. Cancer Res. 2004 May 1;64(9):3344 LP – 3349.
(21) Ludwig I, Clifford M, Lean M, Ashihara H, Crozier A. Coffee: biochemistry and potential impact on health. Food Funct. 2014;5:1695–717.
(22) Cavin C, Holzhaeuser D, Scharf G, Constable A, Huber WW, Schilter B. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol. 2002;40(8):1155–63.
(23) Gross G, Jaccaud E, Huggett AC. Analysis of the content of the diterpenes cafestol and kahweol in coffee brews. Food Chem Toxicol. 1997;35(6):547–54.
(24) Miranda J, Monteiro L, Albuquerque R, Pacheco J, Khan Z, Lopez-Lopez J, et al. Coffee is protective against oral and pharyngeal cancer: A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2017;22(5):e554-61.
(25) Shea B, Reeves B, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;21(358):j4008.
(26) Guyatt GH, et al. GRADE guidelines: 7. Rating the quality of evidencedi nconsistency. J Clin Epidemiol. 2011;64:1294–320.
(27) Guyatt GH, Al. E. GRADE guidelines 6. Rating the quality of evidenced imprecision. J Clin Epidemiol. 2011;64:1283e1293.
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