Effects of naringin in combination with exercise on clinical outcmes: A Systematic Review

Authors

  • Abdel Kerim Raffoul Orozco Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain. http://orcid.org/0000-0003-2178-5129
  • Ana Elisa Ávila González Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain.
  • José María Cancela Carral Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain.

DOI:

https://doi.org/10.14306/393

Keywords:

naringin, Exercise, Dietary Supplements, Review.

Abstract

Introduction: Naringin is a flavonoid used as a dietary supplement, which is marketed in products for athletes, is promoted as enhancer of other supplements, increases physical capacity and as a "fat burner" for weight loss, among other effects. Objective: To evaluate the available evidence of the effect of oral naringin supplementation in combination with physical activity and / or exercise on clinical responses compared with physical activity and exercise alone.

Material and methods: A systematic search was carried out in electronic databases. Data sources were Science Direct, MEDLINE, PubMed, Web of Science, Cochrane Central Register of Controlled Trials, SPORTDiscus. Selection of studies was publications aiming to study the effects of naringin in combination with exercise or physical activity. Data extraction and synthesis method: Two reviewers analyzed data; data extracted: authors, year of publication, study design, universe of study, intervention and relevant results; quality was quantified with the PEDro scale. The review was carried out following the PRISMA guidelines.

Results: Three clinical trials were identified (mean PEDro score of 8.3). Naringin improves physical activity time and decreases fatigue time, and subjectively improves physical condition but was not statistically better than placebo.

Conclusions: Studies show contradictions about the effects of the combination on physical fitness.

Author Biographies

Abdel Kerim Raffoul Orozco, Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain.

Universidade de Vigo

Departamento de Didácticas Especiais

Área de Educación Física e Deportiva.

Estudiante Post-Doctorado

Ana Elisa Ávila González, Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain.

Universidade de Vigo

Departamento de Didácticas Especiais

Área de Educación Física e Deportiva.

Estudiante Post-Doctorado

José María Cancela Carral, Área de Educación Física e Deportiva, Departamento de Didácticas Especiais, Facultade de Ciencias da Educación e do Deporte, Universidade de Vigo. Vigo, Spain.

 

Profesor Titular de Universidade

Área de Educación Física e Deportiva.

Grupo Healthyfit

Departamento de Didácticas Especiais

Universidade de Vigo

Facultade de Ciencias da Educación e do Deporte

References

(1) Bharti S, Rani N, Krishnamurthy B, Arya DS. Preclinical evidence for the pharmacological actions of naringin: a review. Planta Med. 2014;80(6):437-51.

(2) Morand C, Dubray C, Milenkovic D, Lioger D, Martin JF, Scalbert A, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr. 2011;93(1):73-80.

(3) Cilla A. Actividad antioxidante y biodisponibilidad mineral de zumos de frutas adicionados de minerales y/o leche [Internet]. [Valencia, España]: Universitat de València; 2010. Disponible en: https://dialnet.unirioja.es/servlet/tesis?codigo=83658

(4) Ishii K, Furuta T, Kasuya Y. Determination of naringin and naringenin in human urine by high-performance liquid chromatography utilizing solid-phase extraction. J Chromatogr B Biomed Sci Appl. 1997;704(1-2):299-305.

(5) Shirasaka Y, Shichiri M, Mori T, Nakanishi T, Tamai I. Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. J Pharm Sci. 2013;102(1):280-8.

(6) Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010;70(5):645-55.

(7) Yoshida H, Watanabe W, Oomagari H, Tsuruta E, Shida M, Kurokawa M. Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes. J Nutr Biochem. 2013;24(7):1276-84.

(8) Silver HJ, Dietrich MS, Niswender KD. Effects of grapefruit, grapefruit juice and water preloads on energy balance, weight loss, body composition, and cardiometabolic risk in free-living obese adults. Nutr Metab (Lond). 2011;8(1):8.

(9) Dyrøy E, Røst TH, Pettersen RJ, Halvorsen B, Gudbrandsen OA, Ueland T, et al. Tetradecylselenoacetic Acid, a PPAR Ligand With Antioxidant, Antiinflammatory, and Hypolipidemic Properties. Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27(3):628-34.

(10) Medjakovic S, Mueller M, Jungbauer A. Potential health-modulating effects of isoflavones and metabolites via activation of PPAR and AhR. Nutrients. 2010;2(3):241-79.

(11) Jung UJ, Kim HJ, Lee JS, Lee MK, Kim HO, Park EJ, et al. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin Nutr. 2003;22(6):561-8.

(12) Shen W, Xu Y, Lu Y-H. Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells. J Agric Food Chem. 2012;60(38):9609-19.

(13) Osman HE, Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. J Nutr. 1998;128(12):2307-12.

(14) Xu C, Chen J, Zhang J, Hu X, Jiang H. Naringenin inhibits vascular smooth muscle cell function involving reactive oxygen species production modulation and NF-κB activity suppression. Heart. 2011;97(Suppl 3):A83-A83.

(15) Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74(5):603-12.

(16) Alam MA, Kauter K, Brown L. Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats. Nutrients. 2013;5(3):637-50.

(17) Zhang YD, Lorenzo B, Reidenberg MM. Inhibition of 11 beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol. 1994;49(1):81-5.

(18) Zhang YD, Wang MS. Inhibition of 11 beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by some bioflavonoids and triterpenoids. Zhongguo Yao Li Xue Bao. 1997;18(3):240-4.

(19) Saponara S, Testai L, Iozzi D, Martinotti E, Martelli A, Chericoni S, et al. (+/-)-Naringenin as large conductance Ca(2+)-activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 2006;149(8):1013-21.

(20) Jeon S-M, Park YB, Choi M-S. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clin Nutr. 2004;23(5):1025-34.

(21) Becerra J. Los flavonoides del pomelo y el sistema desintoxicador celular [Internet]. Encuentros en la biología. 2000 [citado 18 de febrero de 2016]. Disponible en: http://www.encuentros.uma.es/encuentros66/pomelo.htm

(22) Russo RO, Speranza Sánchez M. Los flavonoides en la terapia cardiovascular. Rev Costarric Cardiol. 2006;8(1):13-8.

(23) Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol. 1998;51(12):1235-41.

(24) Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713-21.

(25) van Tulder M, Furlan A, Bombardier C, Bouter L, Editorial Board of the Cochrane Collaboration Back Review Group. Updated method guidelines for systematic reviews in the cochrane collaboration back review group. Spine. 2003;28(12):1290-9.

(26) Morales-Osorio MA, Mejía-Mejía JM. Tratamiento con imaginería motora graduada en el síndrome de miembro fantasma con dolor: una revisión sistemática. Rehabilitación. 2012;46(4):310-6.

(27) Hoffman JR, Ratamess NA, Gonzalez A, Beller NA, Hoffman MW, Olson M, et al. The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. J Int Soc Sports Nutr. 2010;7:39.

(28) Aptekmann NP, Cesar TB. Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training. Maturitas. 2010;67(4):343-7.

(29) Haller CA, Duan M, Jacob P, Benowitz N. Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol. 2008;65(6):833-40.

(30) Gordt K, Gerhardy T, Najafi B, Schwenk M. Effects of Wearable Sensor-Based Balance and Gait Training on Balance, Gait, and Functional Performance in Healthy and Patient Populations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Gerontology. 2018;64(1):74-89.

(31) Wang Y, Xu D. Effects of aerobic exercise on lipids and lipoproteins. Lipids Health Dis. 2017;16(1):132.

(32) Kim S-Y, Kim H-J, Lee M-K, Jeon S-M, Do G-M, Kwon E-Y, et al. Naringin time-dependently lowers hepatic cholesterol biosynthesis and plasma cholesterol in rats fed high-fat and high-cholesterol diet. J Med Food. 2006;9(4):582-6.

Published

2018-03-30

How to Cite

Raffoul Orozco, A. K., Ávila González, A. E., & Cancela Carral, J. M. (2018). Effects of naringin in combination with exercise on clinical outcmes: A Systematic Review. Spanish Journal of Human Nutrition and Dietetics, 22(1), 21–30. https://doi.org/10.14306/393