Clinical Practice Guidelines for nutritional management of Cystic Fibrosis patients (GPC-CF)
DOI:
https://doi.org/10.14306/renhyd.21.1.229Keywords:
Cystic Fibrosis, Diet Therapy, Practice Guidelines as TopicAbstract
Cystic fibrosis (CF) is a multiorgan, hereditary, autosomal and recessive disease whose most frequent problems are related to alterations of the lungs and exocrine pancreas. The objective of this guide is to establish guidelines in clinical practice for the nutritional management of people with CF. Recommendations on the evaluation of clinical and nutritional status (anamnesis, physical examination, body composition, biochemistry, lung function, nutritional nutrition and Weight loss, nutritional nutrition, vitamin and mineral supplementation, treatment of pancreatic insufficiency, diabetes, and liver disease) and other circumstances (pregnancy, lactation, and lung transplantation) also can be found in this guide. The guideline has been developed through a simple review by a group of experts who made decisions by consensus to assist in the decision making of professionals involved in patient care. This guide has been reviewed and approved by the Scientific Committee of the Spanish Foundation of Dieticians and Nutritionists (FEDN). This guide is not intended to be mandatory nor to replace the clinical judgment of health personnel.References
(1) Bousoño C, Pérez J. Fibrosis Quística: del ayer al hoy. En: Salcedo P, Gartner S, Girón RM, García MD, editores. Tratado de Fibrosis Quística. 1 ed. Editorial Justim; 2012. p. 17-27.
(2) Morales P, Sánchez E. Capítulo 1. Identificación, estructura y expresión del gen CFTR. En: Salcedo P, Gartner S, Girón RM, García MD, editores. Tratado de Fibrosis Quística. 1 ed. Editorial Justim; 2012. p. 29-40.
(3) Ministerio de Sanidad y Consumo. ¿Qué es y cómo se produce? En: Fibrosis quística: guía para pacientes y familiares. Ministerio de Sanidad y Consumo, Publicaciones, Documentación y Biblioteca; 1998. p. 15-25.
(4) Yankaskas JR, Marshall BC, Sufian B, Simon RH, Rodman D. Cystic fibrosis adult care: consensus conference report. Chest. 2004;125(1 Suppl):1S-39S.
(5) Federación Española contra la Fibrosis Quística. Los tres pilares del tratamiento en fibrosis quística: antibioterapia, fisioterapia y nutrición. Valencia, España: Federación Española contra la Fibrosis Quística; 2016.
(6) Sinaasappel M, Stern M, Littlewood J, Wolfe S, Steinkamp G, Heijerman HGM, et al. Nutrition in patients with cystic fibrosis: a European Consensus. J Cyst Fibros. 2002;1(2):51-75.
(7) Smyth AR, Bell SC, Bojcin S, Bryon M, Duff A, Flume P, et al. European Cystic Fibrosis Society Standards of Care: Best Practice guidelines. J Cyst Fibros. 2014;13 Suppl 1:S23-42.
(8) Kerem E, Conway S, Elborn S, Heijerman H, Consensus Committee. Standards of care for patients with cystic fibrosis: a European consensus. J Cyst Fibros. 2005;4(1):7-26.
(9) Fundación Sira Carrasco. Consenso sobre intervención nutricional en la Fibrosis Quística. Fundación Sira Carrasco; 1999.
(10) Martínez C, Pedrón C. Valoración del estado nutricional. En: Protocolos diagnóstico-terapéuticos de Gastroenterología, Hepatología y Nutrición Pediátrica SEGHNP-AEP. 2 ed. Madrid, España: Ergón; 2010. p. 313-8. (Protocolos de la AEP).
(11) Borowitz D, Baker RD, Stallings V. Consensus report on nutrition for pediatric patients with cystic fibrosis. J Pediatr Gastroenterol Nutr. 2002;35(3):246-59.
(12) Hernández M, Castellet J, Narvaiza JL, Rincón JM, Ruiz I, Sánchez E, et al. Curvas y Tablas de Crecimiento. Madrid, España: Editorial Garsi; 1988.
(13) Longas AF, Baguer L, Labarta JI, Labena C, Mayayo E, Puga B, et al. Longitudinal study of normal spanish children from birth to adulthood anthropometric, puberty, radiological and intellectual data. Pediatr Endocrinol Rev. 2005;2(Suppl 4):425.
(14) Fernández C, Lorenzo H, Vrotsou K, Aresti U, Rica I, Sánchez E. Estudio de crecimiento de Bilbao: curvas y tablas de crecimiento (Estudio transversal). Bilbao, España: Fundación Faustino Orbegozo Eizaguirre; 2011.
(15) World Health Organization. WHO child growth standards : length/height-for-age, weight-for-age, weight-for-length, weight-for- height and body mass index-for-age : methods and development. France: World Health Organization; 2006.
(16) Stallings VA, Stark LJ, Robinson KA, Feranchak AP, Quinton H, Clinical Practice Guidelines on Growth and Nutrition Subcommittee, et al. Evidence-based practice recommendations for nutrition-related management of children and adults with cystic fibrosis and pancreatic insufficiency: results of a systematic review. J Am Diet Assoc. 2008;108(5):832-9.
(17) Escobar H. 23g Tratamiento nutricional en la fibrosis quística. En: Manual Práctico de Nutrición en Pediatría. Madrid, España: Ergon; 2007. p. 348-53.
(18) Yen EH, Quinton H, Borowitz D. Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis. J Pediatr. 2013;162(3):530-535.e1.
(19) McDonald CM. Validation of a nutrition risk screening tool for children and adolescents with cystic fibrosis ages 2-20 years. J Pediatr Gastroenterol Nutr. 2008;46(4):438-46.
(20) Groeneweg M, Tan S, Boot AM, de Jongste JC, Bouquet J, Sinaasappel M. Assessment of nutritional status in children with cystic fibrosis: conventional anthropometry and bioelectrical impedance analysis. A cross-sectional study in Dutch patients. J Cyst Fibros. 2002;1(4):276-80.
(21) Hollander FM, De Roos NM, De Vries JHM, Van Berkhout FT. Assessment of nutritional status in adult patients with cystic fibrosis: whole-body bioimpedance vs body mass index, skinfolds, and leg-to-leg bioimpedance. J Am Diet Assoc. 2005;105(4):549-55.
(22) Lama R, Carrasco S, Codoceo R, Soto D, Martínez MC, Antelo MC. Composición corporal y gasto energético en reposo en el niño con FQ. En: III Congreso Nacional de Fibrosis Quística. Valencia, España; 1995.
(23) Martínez-Costa C, Escribano A, Núñez F, García-Maset L, Luján J, Martínez-Rodríguez L. Intervención nutricional en niños y adolescentes con fibrosis quística. Relación con la función pulmonar. Nutr Hosp. 2005;20(3):182-8.
(24) Turck D, Braegger CP, Colombo C, Declercq D, Morton A, Pancheva R, et al. ESPEN-ESPGHAN-ECFS guidelines on nutrition care for infants, children, and adults with cystic fibrosis. Clin Nutr. 2016;35(3):557-77.
(25) Cystic Fibrosis Foundation, Borowitz D, Robinson KA, Rosenfeld M, Davis SD, Sabadosa KA, et al. Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis. J Pediatr. 2009;155(6 Suppl):S73-93.
(26) Lahiri T, Hempstead SE, Brady C, Cannon CL, Clark K, Condren ME, et al. Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis. Pediatrics. 2016;137(4).
(27) Barja S, Rebollo MJ. Manejo Nutricional en Niños y Adolescentes con Fibrosis Quística. Rev Chil Pediatr. 2009;80(3):274-84.
(28) Ramsey BW, Farrell PM, Pencharz P. Nutritional assessment and management in cystic fibrosis: a consensus report. The Consensus Committee. Am J Clin Nutr. 1992;55(1):108-16.
(29) United Nations University, World Health Organization, Food and Agriculture Organization of the United Nations. Human Energy Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation : Rome, 17-24 October 2001. FAO; 2004. (FAO: Food and Nutrition Technical Report Series).
(30) Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, D.C.: The National Academies Press; 2005.
(31) Schofield WN. Predicting basal metabolic rate, new standards and review of previous work. Hum Nutr Clin Nutr. 1985;39 Suppl 1:5-41.
(32) Harris JA, Benedict FG. A Biometric Study of Human Basal Metabolism. Proc Natl Acad Sci USA. 1918;4(12):370-3.
(33) Roza AM, Shizgal HM. The Harris Benedict equation reevaluated: resting energy requirements and the body cell mass. Am J Clin Nutr. 1984;40(1):168-82.
(34) Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr. 1990;51(2):241-7.
(35) Olveira G, Laínez M. Importancia del soporte nutricional en adultos con fibrosis quística. Endocrinol Nutr. 2006;53(5):326-34.
(36) Kalnins D, Wilschanski M. Maintenance of nutritional status in patients with cystic fibrosis: new and emerging therapies. Drug Des Devel Ther. 2012;6:151-61.
(37) Sermet-Gaudelus I, Mayell SJ, Southern KW, European Cystic Finrosis Society (ECFS), Neonatal Screening Working Group. Guidelines on the early management of infants diagnosed with cystic fibrosis following newborn screening. J Cyst Fibros. 2010;9(5):323-9.
(38) Littlewood JM, Wolfe SP, Conway SP. Diagnosis and treatment of intestinal malabsorption in cystic fibrosis. Pediatr Pulmonol. 2006;41(1):35-49.
(39) Unidad de Diabetes Pediátrica del Hospital Universitario Ramón y Cajal. Lo que debes saber sobre la diabetes relacionada con la fibrosis quística (DRFQ). Madrid, España: Federación Española de Fibrosis Quística; 2009.
(40) Brunzell C, Hardin DS, Moran A, Schindler T. Managing Cystic Fibrosis-Related Diabetes (CFRD): An Instruction Guide for Patients and Families. 5 ed. Bethesda, MD: Cystic Fibrosis Foundation; 2011.
(41) Moyer K, Balistreri W. Hepatobiliary disease in patients with cystic fibrosis. Curr Opin Gastroenterol. 2009;25(3):272-8.
(42) Parisi GF, Di Dio G, Franzonello C, Gennaro A, Rotolo N, Lionetti E, et al. Liver disease in cystic fibrosis: an update. Hepat Mon. 2013;13(8):e11215.
(43) Colombo C, Battezzati PM, Crosignani A, Morabito A, Costantini D, Padoan R, et al. Liver disease in cystic fibrosis: A prospective study on incidence, risk factors, and outcome. Hepatology. 2002;36(6):1374-82.
(44) Woodruff SA, Sontag M, Accurso F, Sokol RJ, Narkewicz MR. Prevalence of elevated liver function tests in children with cystic fibrosis diagnosed by newborn screen. En: North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting, October 25-27, 2007. Salk Lake City, Utah: J Pediatr Gastroenterol Nutr. 2007; 45 (4): E27-8;
(45) Silva FA de A, Dodge JA, WHO Human Genetics Programme, International Cystic Fibrosis (Mucoviscidosis Association). Guidelines for the diagnosis and management of cystic fibrosis. World Health Organization; 1996.
(46) Debray D, Kelly D, Houwen R, Strandvik B, Colombo C. Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease. J Cyst Fibros. 2011;10(Suppl 2):S29-36.
(47) Acuña MD, Martínez MJ. Capítulo 24. Enfermedad intestinal: fisiopatología, clínica y tratamiento. En: Salcedo A, Gartner S, Girón RM, García MD, editores. Tratado de Fibrosis Quística. 1 ed. Editorial Justim; 2012. p. 319-23.
(48) Matel JL, Milla CE. Nutrition in cystic fibrosis. Semin Respir Crit Care Med. 2009;30(5):579-86.
(49) González D, Díaz JJ, Bousoño C, Rivas C, Acuña MD, Heredia S, et al. Estado Nutricional en pacientes pediátricos con fibrosis quística. Bol Pediatr. 2012;52(219):14-8.
(50) Olveira G, Olveira C. Nutrición, fibrosis quística y aparato digestivo. Nutr Hosp. 2008;23(Suppl 2):71-86.
(51) Olveira G, Ayúcar A. Fibrosis quística. En: León M, Celaya S, Álvarez J, editores. Manual de recomendaciones nutricionales al alta hospitalaria. 2 ed. Barcelona: Glosa; 2010. p. 278-85.
(52) López-Legarrea P, Martínez JA. Nutrición en el enfermo con fibrosis quística. Nutr clín diet hosp. 2010;30(2):13-9.
(53) Lessen R, Kavanagh K. Position of the academy of nutrition and dietetics: promoting and supporting breastfeeding. J Acad Nutr Diet. 2015;115(3):444-9.
(54) Kramer MS, Kakuma R. Optimal duration of exclusive breastfeeding. Cochrane Database Syst Rev. 2012;(8):CD003517.
(55) Munck A. Nutritional considerations in patients with cystic fibrosis. Expert Rev Respir Med. 2010;4(1):47-56.
(56) Bankhead R, Boullata J, Brantley S, Corkins M, Guenter P, Krenitsky J, et al. Enteral nutrition practice recommendations. JPEN J Parenter Enteral Nutr. 2009;33(2):122-67.
(57) Moreno JM. Nutrición enteral y parenteral en pediatría. Endocrinol Nutr. 2004;51(4):183-96.
(58) Finklea JD, Grossmann RE, Tangpricha V. Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies. Adv Nutr. 2011;2(3):244-53.
(59) Tangpricha V, Kelly A, Stephenson A, Maguiness K, Enders J, Robinson KA, et al. An update on the screening, diagnosis, management, and treatment of vitamin D deficiency in individuals with cystic fibrosis: evidence-based recommendations from the Cystic Fibrosis Foundation. J Clin Endocrinol Metab. 2012;97(4):1082-93.
(60) Hall WB, Sparks AA, Aris RM. Vitamin d deficiency in cystic fibrosis. Int J Endocrinol. 2010;2010:218691.
(61) Elkin SL, Vedi S, Bord S, Garrahan NJ, Hodson ME, Compston JE. Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am J Respir Crit Care Med. 2002;166(11):1470-4.
(62) Aris RM, Merkel PA, Bachrach LK, Borowitz DS, Boyle MP, Elkin SL, et al. Guide to bone health and disease in cystic fibrosis. J Clin Endocrinol Metab. 2005;90(3):1888-96.
(63) Grupo Técnico (Programa de Fibrosis Quística) de la Unidad de Salud Respiratoria, Ministerio de Salud (Chile). Programa Nacional de Fibrosis Quística: Orientaciones Técnicas Programáticas para Diagnóstico y Tratamiento. Subsecretaría de Redes Asistenciales; 2012.
(64) Davis PB. Cystic fibrosis since 1938. Am J Respir Crit Care Med. 2006;173(5):475-82.
(65) Matel JL. Nutritional management of cystic fibrosis. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):60S-7S.
(66) Ferrie S, Graham C, Hoyle M. Pancreatic enzyme supplementation for patients receiving enteral feeds. Nutr Clin Pract. 2011;26(3):349-51.
(67) Moran A, Brunzell C, Cohen RC, Katz M, Marshall BC, Onady G, et al. Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society. Diabetes Care. 2010;33(12):2697-708.
(68) American Diabetes Association. Approaches to glycemic treatment. Sec. 7. Diabetes Care. 2015;38(Suppl 1):S41-8.
(69) World Health Organization. Guideline: Sugars intake for adults and children [Internet]. Geneva: World Health Organization; 2015 [citado 7 de febrero de 2017]. (WHO Guidelines Approved by the Guidelines Review Committee). Disponible en: http://www.ncbi.nlm.nih.gov/books/NBK285537/
(70) Barrio R, Muñoz MT. Capítulo 31. Enfermedad pancreática endocrina: fisiopatología, clínica, despistaje y tratamiento. En: Salcedo A, Gartner S, Girón RM, García MD, editores. Tratado de Fibrosis Quística. 1 ed. Editorial Justim; 2012. p. 405-16.
(71) Sokol RJ, Durie PR. Recommendations for management of liver and biliary tract disease in cystic fibrosis. Cystic Fibrosis Foundation Hepatobiliary Disease Consensus Group. J Pediatr Gastroenterol Nutr. 1999;28(Suppl 1):S1-13.
(72) Cystic Fibrosis Trust. Nutritional Management of cystic fibrosis - April 2002. 1 ed. Bromley, UK: Cystic Fibrosis Trust; 2014.
(73) Edenborough FP, Borgo G, Knoop C, Lannefors L, Mackenzie WE, Madge S, et al. Guidelines for the management of pregnancy in women with cystic fibrosis. J Cyst Fibros. 2008;7(Suppl 1):S2-32.
(74) Moshang T, Holsclaw DS. Menarchal determinants in cystic fibrosis. Am J Dis Child. 1980;134(12):1139-42.
(75) Worthington-Roberts B. Preconceptional and prenatal nutrition: part 1 energy, protein and related issues. J Can Diet Assoc. 1985;46:169-75.
(76) Harlap S, Shiono PH. Alcohol, smoking, and incidence of spontaneous abortions in the first and second trimester. Lancet. 1980;2(8187):173-6.
(77) Jelalian E, Stark LJ, Reynolds L, Seifer R. Nutrition intervention for weight gain in cystic fibrosis: a meta analysis. J Pediatr. 1998;132(3 Pt 1):486-92.
(78) Rosenfeld M, Casey S, Pepe M, Ramsey BW. Nutritional effects of long-term gastrostomy feedings in children with cystic fibrosis. J Am Diet Assoc. 1999;99(2):191-4.
(79) De-Regil LM, Fernández-Gaxiola AC, Dowswell T, Peña-Rosas JP. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2010;(10):CD007950.
(80) Committee on Medical Aspects of Food and Nutrition Policy. Folic acid and the prevention of disease: report of the Committee on Medical Aspects of Food and Nutrition Policy. London: The Stationery Office; 2000. (Reports on health and social subjects).
(81) World Health Organization. Safe vitamin A dosage during pregnancy and lactation : recommendations and report of a consultation. Geneva: World Health Organization; 1998. (Micronutrient series).
(82) Rothman KJ, Moore LL, Singer MR, Nguyen US, Mannino S, Milunsky A. Teratogenicity of high vitamin A intake. N Engl J Med. 1995;333(21):1369-73.
(83) Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003;77(1):204-10.
(84) De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2012;(2):CD008873.
(85) Peña-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012;12:CD004736.
(86) Browne ML. Maternal exposure to caffeine and risk of congenital anomalies: a systematic review. Epidemiology. 2006;17(3):324-31.
(87) American College of Obstetricians and Gynecologists. ACOG CommitteeOpinion No. 462: Moderate caffeine consumption during pregnancy. Obstet Gynecol. 2010;116(2 Pt 1):467-8.
(88) Leventakou V, Roumeliotaki T, Martinez D, Barros H, Brantsaeter A-L, Casas M, et al. Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies. Am J Clin Nutr. 2014;99(3):506-16.
(89) Secretaría General de Sanidad. Guía para la Prevención de Defectos Congénitos. Madrid, España: Ministerio de Sanidad y Consumo; 2006.
(90) Consell de Collegis farmacèutics de Catalunya, Agència Catalana de Seguretat Alimentària. Fichas de seguridad alimentaria: consejos para embarazadas: La Toxoplasmosis. Generalitat de Catalunya; 2012.
(91) Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines. Weight Gain During Pregnancy: Reexamining the Guidelines. Rasmussen KM, Yaktine AL, editores. Washington (DC): National Academies Press (US); 2009. (The National Academies Collection: Reports funded by National Institutes of Health).
(92) Hilman BC, Aitken ML, Constantinescu M. Pregnancy in patients with cystic fibrosis. Clin Obstet Gynecol. 1996;39(1):70-86.
(93) Feig DS, Naylor CD. Eating for two: are guidelines for weight gain during pregnancy too liberal? Lancet. 1998;351(9108):1054-5.
(94) Valenzuela GJ, Comunale FL, Davidson BH, Dooley RR, Foster TC. Clinical management of patients with cystic fibrosis and pulmonary insufficiency. Am J Obstet Gynecol. 1988;159(5):1181-3.
(95) Alpert SE, Cormier AD. Normal electrolyte and protein content in milk from mothers with cystic fibrosis: an explanation for the initial report of elevated milk sodium concentration. J Pediatr. 1983;102(1):77-80.
(96) Shiffman ML, Seale TW, Flux M, Rennert OR, Swender PT. Breast-milk composition in women with cystic fibrosis: report of two cases and a review of the literature. Am J Clin Nutr. 1989;49(4):612-7.
(97) Bitman J, Hamosh M, Wood DL, Freed LM, Hamosh P. Lipid composition of milk from mothers with cystic fibrosis. Pediatrics. 1987;80(6):927-32.
(98) Golembeski DJ, Emery MG. Lipid composition of milk from mothers with cystic fibrosis. Pediatrics. 1989;83(4 Pt 2):631-2.
(99) Fairweather-Tait S, Prentice A, Heumann KG, Jarjou LM, Stirling DM, Wharf SG, et al. Effect of calcium supplements and stage of lactation on the calcium absorption efficiency of lactating women accustomed to low calcium intakes. Am J Clin Nutr. 1995;62(6):1188-92.
(100) Kerem E, Reisman J, Corey M, Canny GJ, Levison H. Prediction of mortality in patients with cystic fibrosis. N Engl J Med. 1992;326(18):1187-91.
(101) Augarten A, Akons H, Aviram M, Bentur L, Blau H, Picard E, et al. Prediction of mortality and timing of referral for lung transplantation in cystic fibrosis patients. Pediatr Transplant. 2001;5(5):339-42.
(102) Madden BP, Kamalvand K, Chan CM, Khaghani A, Hodson ME, Yacoub M. The medical management of patients with cystic fibrosis following heart-lung transplantation. Eur Respir J. 1993;6(7):965-70.
(103) Taylor DO, Edwards LB, Boucek MM, Trulock EP, Aurora P, Christie J, et al. Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report--2007. J Heart Lung Transplant. 2007;26(8):769-81.
(104) Ishani A, Erturk S, Hertz MI, Matas AJ, Savik K, Rosenberg ME. Predictors of renal function following lung or heart-lung transplantation. Kidney Int. 2002;61(6):2228-34.
(105) Ojo AO, Held PJ, Port FK, Wolfe RA, Leichtman AB, Young EW, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med. 2003;349(10):931-40.
(106) Bloom RD, Doyle AM. Kidney disease after heart and lung transplantation. Am J Transplant. 2006;6(4):671-9.
(107) Esposito C, De Mauri A, Vitulo P, Oggionni T, Cornacchia F, Valentino R, et al. Risk factors for chronic renal dysfunction in lung transplant recipients. Transplantation. 2007;84(12):1701-3.
(108) Walli AK, Gröne E, Miller B, Gröne HJ, Thiery J, Seidel D. Role of lipoproteins in progressive renal disease. Am J Hypertens. 1993;6(11 Pt 2):358S-366S.
(109) Griffiths MH, Crowe AV, Papadaki L, Banner NR, Yacoub MH, Thompson FD, et al. Cyclosporin nephrotoxicity in heart and lung transplant patients. QJM. 1996;89(10):751-64.
(110) Zietse R, Balk AH, vd Dorpel MA, Meeter K, Bos E, Weimar W. Time course of the decline in renal function in cyclosporine-treated heart transplant recipients. Am J Nephrol. 1994;14(1):1-5.
(111) Kalnins D, Pencharz PB, Grasemann H, Solomon M. Energy expenditure and nutritional status in pediatric patients before and after lung transplantation. J Pediatr. 2013;163(5):1500-2.
(112) Bodet-Milin C, Querellou S, Oudoux A, Haloun A, Horeau-Llanglard D, Carlier T, et al. Delayed gastric emptying scintigraphy in cystic fibrosis patients before and after lung transplantation. J Heart Lung Transplant. 2006;25(9):1077-83.
(113) Belkin RA, Henig NR, Singer LG, Chaparro C, Rubenstein RC, Xie SX, et al. Risk factors for death of patients with cystic fibrosis awaiting lung transplantation. Am J Respir Crit Care Med. 2006;173(6):659-66.
(114) Gilljam M, Chaparro C, Tullis E, Chan C, Keshavjee S, Hutcheon M. GI complications after lung transplantation in patients with cystic fibrosis. Chest. 2003;123(1):37-41.
(115) Atkins BZ, Petersen RP, Daneshmand MA, Turek JW, Lin SS, Davis RD. Impact of oropharyngeal dysphagia on long-term outcomes of lung transplantation. Ann Thorac Surg. 2010;90(5):1622-8.
(116) Leonard A, Schindler T. Cystic Fibrosis Nutrition 101: Getting Started. 2014.
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